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Full-Text Articles in Biomedical Engineering and Bioengineering
Effects Of Hypertension And Aging On Vascular Smooth Muscle Cell Contribution To Reconstituted Aortic Tissue Stiffness, Nancy Lisa Sehgel
Effects Of Hypertension And Aging On Vascular Smooth Muscle Cell Contribution To Reconstituted Aortic Tissue Stiffness, Nancy Lisa Sehgel
Theses
Aortic stiffness increases with hypertension and aging, and much of this increase has been thought to occur due to changes in the extracellular matrix. However, an increase in cell stiffness could also be important. To study the cellular contribution to aortic stiffness, a reconstituted aortic tissue model (composed of vascular smooth muscle cells (VSMCs) in a collagen matrix) was developed. VSMCs isolated from thoracic aortic samples of 5-week and 18-week old male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats were passaged four times and then separately incubated in collagen for two days on a cylindrical mandrel. The resulting …
The Influence Of Exercise On Oxygen Uptake In Mild Hypertension, Matthew Joseph Herban
The Influence Of Exercise On Oxygen Uptake In Mild Hypertension, Matthew Joseph Herban
Theses
The amount of oxygen used by muscle cells increase with exercise. The two body systems that influence the amount of oxygen delivered are the cardiovascular system and the pulmonary system. Two groups of patients were studied, those that were mildly hypertensive (but are not taking prescription medication for hypertension) and the control or normal group. The two groups exercised on a bicycle ergometer. Work rate was increased in steps (multiples of thirty watts) until anaerobic threshold (as measured by an ear oximeter) was reached. Heart rate, blood pressure, oxygen uptake and carbon dioxide production were measured during exercise. Their data …