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Partial Characterization Of Extruded Collagen Tubes With Varied Material Deposition And Orientation Based On Rotation Rate And Linear Draw Speed, Richard Peter Hoppe
Partial Characterization Of Extruded Collagen Tubes With Varied Material Deposition And Orientation Based On Rotation Rate And Linear Draw Speed, Richard Peter Hoppe
Theses
This study established protocols for extrusion of collagen tubes from an extruder made by the ZOKO Corporation of Czechoslovakia. Using a viscous collagen base material, collagen tubes can be formed with changes in rotation rates from 0 rpm to 260 rpm and linear draw speeds from 383 mm/min to 1270 mm/min with a constant extrusion rate of 50 cm2/min. These tubes, with further research and treatment, can be used for various medical applications including vascular implants and nerve conduits.
Post-extrusion, chemical crosslinking of the collagen increased the cohesiveness and mechanical integrity of the tubes. Microscopic photographs confirmed higher …