Biomedical Engineering and Bioengineering Commons^™

Eeg Characterization During Motor Tasks That Are Difficult For Movement Disorder Patients, Adam Joshua Aslam

Master's Theses

Movement disorders are a group of syndromes that often arise due to neurological abnormalities. Approximately 40 million Americans are affected by some form of movement disorder, significantly impacting patients’ quality of life and their ability to live independently. Deep brain stimulation (DBS) is one treatment that has shown promising results in the past couple decades, however, the currently used open-loop system has several drawbacks. By implementing a closed-loop or adaptive DBS (aDBS) system, the need for expensive parameter reprogramming sessions would be reduced, side-effects may be relieved, and habituation could be avoided. Several biomarkers, for example signals or activity derived …

The Effects Of Transcutaneous Electrical Neurostimulation On Analgesia And Peripheral Perfusion, Leah I. Schafer

Master's Theses

Peripheral arterial occlusive disease (PAOD) affects 8 to 12 million Americans over the age of 50. As the disease progresses, arterial occlusions arising from atherosclerotic lesions inhibit normal metabolic vasodilation in the peripheries, resulting in limb ischemia and claudication. Pharmacological and surgical treatments currently used to treat both the hemodynamic and pain symptoms associated with PAOD can involve adverse and potentially life-threatening side effects. Thus, there is a need for additional innovative therapies for PAOD.

Neurostimulation has a known analgesic effect on both acute and chronic pain. Although the exact mechanisms remain under investigation, local vascular tone may be modulated …

Investigating Hemodynamic Responses To Electrical Neurostimulation, Sean Youra

Master's Theses

Since the 1900s, the number of deaths attributable to cardiovascular disease has steadily risen. With the advent of antihypertensive drugs and non-invasive surgical procedures, such as intravascular stenting, these numbers have begun to level off. Despite this trend, the number of patients diagnosed with some form of cardiovascular disease has only increased. By 2030, prevalence of coronary heart disease is expected to increase approximately by 18% in the United States. By 2050, prevalence of peripheral arterial occlusive disease is expected to increase approximately by 98% in the U.S. No single drug or surgical intervention offers a complete solution to these …