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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Optimal Control Of A Continuous Bioreactor For Maximized Beta-Carotene Production, Nazmul Karim, Jonathan Raftery, Xinghua Pan
Optimal Control Of A Continuous Bioreactor For Maximized Beta-Carotene Production, Nazmul Karim, Jonathan Raftery, Xinghua Pan
Integrated Continuous Biomanufacturing II
Carotenes such as β-carotene have a positive impact in human health as a precursor of vitamin A. Structural complexity of these compounds makes their chemical synthesis a difficult endeavor, facilitating the need for their biological production. Continuous operation can be used in these processes to allow for increased cell viability through the mitigation of substrate and product inhibition, thereby increasing the productivity of the carotenoid product. This work looks to examine the operating conditions necessary to achieve the maximum production of the desired carotenoid products when produced via continuous operation. First, a two-level parameter estimation method is utilized to develop …
Evaluating Facility Design And Capacity Planning Decisions For Clinical And Commercial Supply With Hybrid Continuous Processes, Suzanne Farid
Evaluating Facility Design And Capacity Planning Decisions For Clinical And Commercial Supply With Hybrid Continuous Processes, Suzanne Farid
Integrated Continuous Biomanufacturing II
Assessing the value potential of alternative process and facility design strategies will be critical to the successful management of continuous processes. UCL’s Decisional Tools team have developed advanced decision-support tools that effectively integrate concepts from bioprocess economics, dynamic simulation, risk analysis, combinatorial optimization and operations research to address such challenges (e.g. 1-5). This presentation will show our latest practical applications of such models to industrially-relevant problems related to facility design and capacity sourcing for long-term commercial supply when dealing with processes with either continuous upstream or downstream processes. The results can be translated across a range of products such as …
Considerations For An Incubation Chamber For Continuous Viral Inactivation, Raquel Orozco, Nancy Guillen, Loleta Chung, Scott Godfrey, Jon Coffman
Considerations For An Incubation Chamber For Continuous Viral Inactivation, Raquel Orozco, Nancy Guillen, Loleta Chung, Scott Godfrey, Jon Coffman
Integrated Continuous Biomanufacturing II
Continuous bioprocessing offers numerous benefits that have been highlighted recently in the literature. While substantial research efforts have allowed for relevant developments in continuous cell culture processes, downstream challenges, such as continuous viral inactivation, have not been addressed. The purpose of this work is to design a chamber that incubates a continuous product stream for a desired incubation time, typically for 1 hour. Since plug-flow cannot be achieved at typical incubation times and flow rates, one of the biggest challenges is to address dispersion of the product stream. Since several logs of viral clearance should be achieved during a virus …