Biomedical Engineering and Bioengineering Commons^™

The Use Of Dynamic Control In Periodic Counter Current Chromatography, Hans Blom, Helena Skoglar

Integrated Continuous Biomanufacturing II

The interest for use of continuous processing in biotech downstream operations is rapidly growing, driven by the gains in productivity, product stability and reduced cost of goods. Continuous processing encompasses a range of different approaches and can relate to both single step operations as well as semi- to fully continuous processes. Improvements in equipment and hardware have now made several commercial systems for continuous chromatography available. As implementation of various strategies for continuous processing becomes more common, the demand/need for reliability in monitoring with existing hardware solutions is steadily increasing. Integration of process analytical technologies will be the determining factor …