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Full-Text Articles in Biomedical Engineering and Bioengineering
Biohazard Neutralization Based On Lipid Technology, Edelmira Bosques
Biohazard Neutralization Based On Lipid Technology, Edelmira Bosques
FIU Electronic Theses and Dissertations
A rapid detection and neutralization method for biowarfare agents would be a great biodefense in war times. With this purpose, liposomes were developed following the lipid film formation, rehydration, and extrusion procedure as the production method. MgOCl2 was encapsulated in the liposomes and it was tested with three different bacterium B. cereus; B. thuringiensis; and B. subtilis. For specificity, the liposomes were modified with a polyclonal antibody against B. cereus and B. subtilis. The liposomes were characterized using a Malvern Zetasizer Instrument, and the study revealed stability of the liposomes stored at 4°C for a …
Development And Evaluation Of A Catheter Deliverable Artificial Aortic Heart Valve Prosthesis And Delivery System, Thomas Edward Claiborne Iii
Development And Evaluation Of A Catheter Deliverable Artificial Aortic Heart Valve Prosthesis And Delivery System, Thomas Edward Claiborne Iii
FIU Electronic Theses and Dissertations
Currently, malfunctioning heart valves are replaced via highly invasive and costly open-heart procedures. A new alternative approach is a catheter deliverable or percutaneous heart valve. Current PHV prototypes utilize fixed animal tissue as valves. This research investigated the feasibility of an artificial PHV and the development of a delivery system. A left hea11 simulator and a tensile tester were used to characterize the hydrodynamics and mechanics of a novel artificial PHV. Test results showed equal or better in vitro hydrodynamic performance when compared to a St. Jude mechanical valve and an Edwards-Sapien PHV, with a mean pressure drop of <15 mmHg and a mean regurgitation of <5%. The PHV's exceeded requirements for fixation and radial force. The 24 F delivery system successfully delivered and deployed a PHV. The work described herein proves the feasibility of an artificial PHV and delivery system and justifies further investigation into its design and function.