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Full-Text Articles in Biomedical Engineering and Bioengineering
Conducting Polypyrrole Hydrogel Biomaterials For Drug Delivery And Cartilage Tissue Regeneration, Iryna Liubchak
Conducting Polypyrrole Hydrogel Biomaterials For Drug Delivery And Cartilage Tissue Regeneration, Iryna Liubchak
Electronic Thesis and Dissertation Repository
Articular cartilage tissue has limited capacity for self-regeneration leading to challenges in the treatment of joint injuries and diseases such as osteoarthritis. The tissue engineering approach combines biomaterials, cells and bioactive molecules to provide a long-term and stable cartilage repair. In the following work, electroactive polymer polypyrrole~(PPy) was incorporated into the synthetic hydrogel to enhance the mechanical properties of the material for cartilage applications. PPy was loaded with drug compound and the \emph{on demand} drug release was demonstrated. The composite PPy hydrogel was 3D printed using stereolithography to create a porous tissue engineering scaffold. Biocompatibility and cell adhesion to the …
Investigation Of Cell Derived Nanoparticles For Drug Delivery And Osteogenic Differentiation Of Human Stem/Stromal Cells, Shruthi Polla Ravi
Investigation Of Cell Derived Nanoparticles For Drug Delivery And Osteogenic Differentiation Of Human Stem/Stromal Cells, Shruthi Polla Ravi
Electronic Thesis and Dissertation Repository
The successful repair of bone defects and injuries is enhanced by the delivery of osteoinductive factors, such as drugs, growth factors, and genetic material that can promote the osteogenic differentiation of stem/stromal cells into osteoblasts. Nanoparticle delivery systems are being studied to enable the sustained release of these factors but suffer from limitations such as cytotoxicity issues, poor loading capacity, and poor cellular uptake. In this project, we developed cell-derived nanoparticles (CDNs), a biomimetic nanoparticle delivery system with high drug loading efficiency, to deliver a glucocorticoid drug, dexamethasone (Dex), to promote the osteogenic differentiation of stem/stromal cells. The synthesized Dex-loaded …