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Full-Text Articles in Biomedical Engineering and Bioengineering
Amine Functionalization Of Bacterial Cellulose For Targeted Delivery Applications, Justin Cook
Amine Functionalization Of Bacterial Cellulose For Targeted Delivery Applications, Justin Cook
Electronic Thesis and Dissertation Repository
Bacterial cellulose (BC), produced by acetic acid bacteria Gluconacetobacter xylinus, is ideal for delivery and related biomedical functions. It is FDA approved for wound dressings and internal applications, non-toxic to endothelial cells and has little effect on blood profiles. Conjugation of therapeutics to BC can be accomplished through the available alcohol groups of the anhydroglucose units (AGU), making targeted delivery possible. Amine was introduced to BC through a reaction involving epichlorohydrin and ammonium hydroxide. The chemical structure was analyzed using infrared spectroscopy and quantified through pH titration. Conjugation of amine to BC was demonstrated through fluorescein-5’-isothiocyanate (FITC) and bromocresol …
Bacterial Cellulose Templates For Nano-Hydroxyapatite Fibre Synthesis, Jordan A. Demello
Bacterial Cellulose Templates For Nano-Hydroxyapatite Fibre Synthesis, Jordan A. Demello
Electronic Thesis and Dissertation Repository
Guided bone regeneration is a medical procedure which induces in vivo re-growth of bone using membranes and osteopromoting fillers. In this work, bacterial cellulose fibers were isolated and used as a basis for biomimetic hydroxyapatite growth, with the ultimate goal of producing GBR filler materials. Acetobacter xylinum generated BC using various carbon sources. Fibers were treated with phosphoric acid to phosphorylate functional groups and preconditioned with calcium to nucleate the HA. Simulated body fluid (SBF) furthered the growth. Over 14 days, the product was characterized via EDX, SEM, FTIR, and XRD. The effect of media composition, phosphorylation time, pretreatment, and …