Biomedical Engineering and Bioengineering Commons^™

Mathematical Characterization Of A Microfluidic Ultrasound Driven Transfection Device., Chris J. Holton

Electronic Theses and Dissertations

The objective of this thesis is to develop a mathematical model characterizing the behavior of a microfluidic sonoporation device in order to understand how standing wave conditions influence molecular delivery to cells and determine whether the model predicts device performance. A prior model based on an ultrasonic separation cell that uses standing waves to separate particles is adapted for translation to the microfluidic device. This study generates data on acoustic pressure profiles across the cell as well as identifying optimal driving frequencies. This model is validated and the equations and methods for developing this model are translated to the microfluidic …