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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Exploration Of Stimulus Current Energy Reduction And Bifurcation Dynamics In Conductance-Based Neuron Models Using Optimal Control Theory, Michael E. Ellinger
Exploration Of Stimulus Current Energy Reduction And Bifurcation Dynamics In Conductance-Based Neuron Models Using Optimal Control Theory, Michael E. Ellinger
Dissertations
Hodgkin-Huxley type conductance-based models can simulate the effect of time-varying injected stimulus currents on the neuron membrane voltage. The dynamics simulated by these model types enables investigation of the biophysical basis of neuronal activity which is fundamental to higher level function. Broadened understanding the basis of nervous system function could lead to development of effective treatment for related diseases, disorders, and the effects of trauma. In this dissertation, optimal control is used with conductance-based neuron models to develop a "Reduced Energy Input Stimulus Discovery Method." Within the method, an objective function balances two competing criteria: tracking a reference membrane voltage …
Monitoring Of Cerebellar Injury Using Micro Ecog Signals In Ketamine/Xylazine Treated Rats, Gokhan Ordek
Monitoring Of Cerebellar Injury Using Micro Ecog Signals In Ketamine/Xylazine Treated Rats, Gokhan Ordek
Dissertations
Much of the cerebellar research has been conducted in anesthetized animals, particularly using ketamine/xylazine combination in rats, and yet the absolute impact of the anesthesia on the neural circuit remains unanswered . In the current study, spontaneous electrical activity and sensory evoked potentials from the cerebellar surface with chronically implanted, flexible-substrate, multielectrode arrays in rats were collected and analyzed with the motor cortex signals. The power spectra and the intercontact coherence plots of the spontaneous activity in the awake-quiet animals extended up to 800 Hz in the cerebellum and only up to 200 Hz in the motor cortex. Ketamine/xylazine anesthesia …