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Biomedical Engineering and Bioengineering Commons

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Chemical and Biological Engineering Publications

2012

Biotin

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Full-Text Articles in Biomedical Engineering and Bioengineering

Structural Classification Of Biotin Carboxyl Carrier Proteins, Yingfei Chen, Armando Elizondo-Noriega, David C. Cantu, Peter J. Reilly Oct 2012

Structural Classification Of Biotin Carboxyl Carrier Proteins, Yingfei Chen, Armando Elizondo-Noriega, David C. Cantu, Peter J. Reilly

Chemical and Biological Engineering Publications

We gathered primary and tertiary structures of acyl-CoA carboxylases from public databases, and established that members of their biotin carboxylase (BC) and biotin carboxyl carrier protein (BCCP) domains occur in one family each and that members of their carboxyl transferase (CT) domains occur in two families. Protein families have members similar in primary and tertiary structure that probably have descended from the same protein ancestor. The BCCP domains complexed with biotin in acyl and acyl-CoA carboxylases transfer bicarbonate ions from BC domains to CT domains, enabling the latter to carboxylate acyl and acyl-CoA moieties. We separated the BCCP domains into ...