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Full-Text Articles in Biomedical Engineering and Bioengineering
Implementation Of Raman Spectroscopy At Manufacturing Scale: Overcoming Modeling Challenges While Implementing Advanced Process Control, John Smelko, Thomas Matthews, Brandon Berry, Douglas Osborne
Implementation Of Raman Spectroscopy At Manufacturing Scale: Overcoming Modeling Challenges While Implementing Advanced Process Control, John Smelko, Thomas Matthews, Brandon Berry, Douglas Osborne
Cell Culture Engineering XV
In order to improve glycation control in our new high intensity platform process, we investigated implementation of Raman spectroscopy to monitor and control glucose at low levels throughout the process. Using Raman allows a way to measure glucose near real time which in turn allows for a more responsive and flexible control algorithm. Prior literature has shown connections between elevated glucose levels and glycation when in presence of high protein concentrations, which was indicative of our process. Using Raman along with advanced process control (APC), allowed us the flexibility to reduce glycation back towards historical process levels.
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