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Murine Hearing Abr/Dpoae Assessments In Cmv-Infected Mouse Pups Receiving Peritoneal Antivirals Of Gcv, Quercetin+P188, Or A Combination. Controls Include Infected And Untreated And Non-Infected And Treated. Second Dataset Of Antiviral Assay In A Murine Stria Vascularis (Sv) Monolayer Cell Culture, David Britt, Albert Park

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Ganciclovir (GCV) has been shown to be an effective antiviral for the treatment of congenital cytomegalovirus (cCMV) induced sensorineural hearing loss. However, dose-dependent adverse effects (e.g. neutropenia) require strict, burdensome monitoring, limiting GCV use in some patients. Quercetin is a flavonoid with antioxidant properties that has demonstrated antiviral therapy against CMV. Although more benign than GCV, quercetin has limited therapeutic value due to its poor solubility. We previously reported that GCV improves hearing thresholds in a murine model of cCMV. We also noted that solubilizing quercetin with poloxamer 188 (P188) and combining with GCV therapy amplified CMV inhibition in murine …