Biomedical Engineering and Bioengineering Commons^™

Lung Circulation Modeling: Status And Prospect, Anne V. Clough, Said H. Audi, Robert C. Molthen, Gary S. Krenz

Biomedical Engineering Faculty Research and Publications

Mathematical modeling has been used to interpret anatomical and physiological data obtained from metabolic and hemodynamic studies aimed at investigating structure-function relationships in the vasculature of the lung, and how these relationships are affected by lung injury and disease. The indicator dilution method was used to study the activity of redox processes within the lung. A steady-state model of the data was constructed and used to show that pulmonary endothelial cells may play an important role in reducing redox active compounds and that those reduction rates can be altered with oxidative stress induced by exposure to high oxygen environments. In …