Biomedical Engineering and Bioengineering Commons^™

Alterations In Cortical Sensorimotor Connectivity Following Complete Cervical Spinal Cord Injury: A Prospective Resting-State Fmri Study, Akinwunmi Oni-Orisan, Mayank Kaushal, Wenjun Li, Jack Leschke, B. Douglas Ward, Aditya Vedantam, Benjamin Kalinosky, Matthew D. Budde, Brian D. Schmit, Shi-Jiang Li, Viashnavi Muqeet, Shekar N. Kurpad

Biomedical Engineering Faculty Research and Publications

Functional magnetic resonance imaging (fMRI) studies have demonstrated alterations during task-induced brain activation in spinal cord injury (SCI) patients. The interruption to structural integrity of the spinal cord and the resultant disrupted flow of bidirectional communication between the brain and the spinal cord might contribute to the observed dynamic reorganization (neural plasticity). However, the effect of SCI on brain resting-state connectivity patterns remains unclear. We undertook a prospective resting-state fMRI (rs-fMRI) study to explore changes to cortical activation patterns following SCI. With institutional review board approval, rs-fMRI data was obtained in eleven patients with complete cervical SCI (>2 years …