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Full-Text Articles in Biomedical Engineering and Bioengineering
Identity And Function Of A Cardiac Mitochondrial Small Conductance Ca2+-Activated K+ Channel Splice Variant, Meiying Yang, Amadou K. S. Camara, Mohammed Aldakkak, Wai-Meng Kwok, David F. Stowe
Identity And Function Of A Cardiac Mitochondrial Small Conductance Ca2+-Activated K+ Channel Splice Variant, Meiying Yang, Amadou K. S. Camara, Mohammed Aldakkak, Wai-Meng Kwok, David F. Stowe
Biomedical Engineering Faculty Research and Publications
We provide evidence for location and function of a small conductance, Ca2+-activated K+ (SKCa) channel isoform 3 (SK3) in mitochondria (m) of guinea pig, rat and human ventricular myocytes. SKCa agonists protected isolated hearts and mitochondria against ischemia/reperfusion (IR) injury; SKCa antagonists worsened IR injury. Intravenous infusion of a SKCa channel agonist/antagonist, respectively, in intact rats was effective in reducing/enhancing regional infarct size induced by coronary artery occlusion. Localization of SK3 in mitochondria was evidenced by Western blot of inner mitochondrial membrane, immunocytochemical staining of cardiomyocytes, and immunogold labeling of isolated mitochondria. …