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Full-Text Articles in Biomedical Engineering and Bioengineering
Non-Common Path Aberration Correction In An Adaptive Optics Scanning Ophthalmoscope, Yusufu N. Sulai, Alfredo Dubra
Non-Common Path Aberration Correction In An Adaptive Optics Scanning Ophthalmoscope, Yusufu N. Sulai, Alfredo Dubra
Biomedical Engineering Faculty Research and Publications
The correction of non-common path aberrations (NCPAs) between the imaging and wavefront sensing channel in a confocal scanning adaptive optics ophthalmoscope is demonstrated. NCPA correction is achieved by maximizing an image sharpness metric while the confocal detection aperture is temporarily removed, effectively minimizing the monochromatic aberrations in the illumination path of the imaging channel. Comparison of NCPA estimated using zonal and modal orthogonal wavefront corrector bases provided wavefronts that differ by ~λ/20 in root-mean-squared (~λ/30 standard deviation). Sequential insertion of a cylindrical lens in the illumination and light collection paths of the imaging channel was used to compare image resolution …
Comparison Of Adaptive Optics Scanning Light Ophthalmoscopic Fluorescein Angiography And Offset Pinhole Imaging, Toco Y.P. Chui, Michael Dubow, Alexander Pinhas, Nishit Shah, Alexander Gan, Rishard Weitz, Yusufu N. Sulai, Alfredo Dubra, Richard B. Rosen
Comparison Of Adaptive Optics Scanning Light Ophthalmoscopic Fluorescein Angiography And Offset Pinhole Imaging, Toco Y.P. Chui, Michael Dubow, Alexander Pinhas, Nishit Shah, Alexander Gan, Rishard Weitz, Yusufu N. Sulai, Alfredo Dubra, Richard B. Rosen
Biomedical Engineering Faculty Research and Publications
Recent advances to the adaptive optics scanning light ophthalmoscope (AOSLO) have enabled finer in vivo assessment of the human retinal microvasculature. AOSLO confocal reflectance imaging has been coupled with oral fluorescein angiography (FA), enabling simultaneous acquisition of structural and perfusion images. AOSLO offset pinhole (OP) imaging combined with motion contrast post-processing techniques, are able to create a similar set of structural and perfusion images without the use of exogenous contrast agent. In this study, we evaluate the similarities and differences of the structural and perfusion images obtained by either method, in healthy control subjects and in patients with retinal vasculopathy …