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Full-Text Articles in Biomedical Engineering and Bioengineering
Functional Classification Of Skeletal Muscle Networks. I. Normal Physiology, Yu Wang, John Winters, Shankar Subramaniam
Functional Classification Of Skeletal Muscle Networks. I. Normal Physiology, Yu Wang, John Winters, Shankar Subramaniam
Biomedical Engineering Faculty Research and Publications
Extensive measurements of the parts list of human skeletal muscle through transcriptomics and other phenotypic assays offer the opportunity to reconstruct detailed functional models. Through integration of vast amounts of data present in databases and extant knowledge of muscle function combined with robust analyses that include a clustering approach, we present both a protein parts list and network models for skeletal muscle function. The model comprises the four key functional family networks that coexist within a functional space; namely, excitation-activation family (forward pathways that transmit a motoneuronal command signal into the spatial volume of the cell and then use Ca …
Functional Classification Of Skeletal Muscle Networks. Ii. Applications To Pathophysiology, Yu Wang, Jack Winters, Shankar Subramaniam
Functional Classification Of Skeletal Muscle Networks. Ii. Applications To Pathophysiology, Yu Wang, Jack Winters, Shankar Subramaniam
Biomedical Engineering Faculty Research and Publications
In our preceding companion paper (Wang Y, Winters J, Subramaniam S. J Appl Physiol. doi: 10.1152/japplphysiol.01514.2011), we used extensive expression profile data on normal human subjects, in combination with legacy knowledge to classify skeletal muscle function into four models, namely excitation-activation, mechanical, metabolic, and signaling-production model families. In this paper, we demonstrate how this classification can be applied to study two well-characterized myopathies: amyotrophic lateral sclerosis (ALS) and Duchenne muscular dystrophy (DMD). Using skeletal muscle profile data from ALS and DMD patients compared with that from normal subjects, normal young in the case of DMD, we delineate molecular mechanisms …