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Full-Text Articles in Biomedical Engineering and Bioengineering
Design And Validation Of Bending Test Method For Characterization Of Miniature Pediatric Cortical Bone Specimens, Carolyne Albert, John Jameson, Gerald F. Harris
Design And Validation Of Bending Test Method For Characterization Of Miniature Pediatric Cortical Bone Specimens, Carolyne Albert, John Jameson, Gerald F. Harris
Biomedical Engineering Faculty Research and Publications
Osteogenesis imperfecta is a genetic disorder of bone fragility; however, the effects of this disorder on bone material properties are not well understood. No study has yet measured bone material strength in humans with osteogenesis imperfecta. Small bone specimens are often extracted during routine fracture surgeries in children with osteogenesis imperfecta. These specimens could provide valuable insight into the effects of osteogenesis imperfecta on bone material strength; however, their small size poses a challenge to their mechanical characterization. In this study, a validated miniature three-point bending test is described that enables measurement of the flexural material properties of pediatric cortical …
An Empirical Method For Correcting The Detector Spectral Response In Energy-Resolved Ct, Taly Gilat Schmidt
An Empirical Method For Correcting The Detector Spectral Response In Energy-Resolved Ct, Taly Gilat Schmidt
Biomedical Engineering Faculty Research and Publications
Energy-resolving photon-counting detectors have the potential for improved material decomposition compared to dual-kVp approaches. However, material decomposition accuracy is limited by the nonideal spectral response of the detectors. This work proposes an empirical method for correcting the nonideal spectral response, including spectrum-tailing effects. Unlike previous correction methods which relied on synchrotron measurements, the proposed method can be performed on the scanner. The proposed method estimates a spectral-response matrix by performing x-ray projection measurements through a range of known thicknesses of two or more calibration materials. Once estimated, the spectral-response matrix is incorporated into conventional material decomposition algorithms. A simulation study …