Biomedical Engineering and Bioengineering Commons^™

Differential Lung Uptake Of 99mtc-Hexamethylpropyleneamine Oxime And 99mtc-Duramycin In The Chronic Hyperoxia Rat Model, Anne V. Clough, Said H. Audi, Steven Thomas Haworth, David L. Roerig

Biomedical Engineering Faculty Research and Publications

Noninvasive radionuclide imaging has the potential to identify and assess mechanisms involved in particular stages of lung injury that occur with acute respiratory distress syndrome, for example. Lung uptake of ^99mTc-hexamethylpropyleneamine oxime (HMPAO) is reported to be partially dependent on the redox status of the lung tissue whereas ^99mTc-duramycin, a new marker of cell injury, senses cell death via apoptosis or necrosis. Thus, we investigated changes in lung uptake of these agents in rats exposed to hyperoxia for prolonged periods, a common model of acute lung injury. Methods: Male Sprague–Dawley rats were preexposed to either normoxia (21% O …