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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Axial Stent Strut Angle Influences Wall Shear Stress After Stent Implantation: Analysis Using 3d Computational Fluid Dynamics Models Of Stent Foreshortening, John F. Ladisa, Lars E. Olson, Douglas Anthony Hettrick, David C. Warltier, Judy R. Kersten, Paul S. Pagel
Axial Stent Strut Angle Influences Wall Shear Stress After Stent Implantation: Analysis Using 3d Computational Fluid Dynamics Models Of Stent Foreshortening, John F. Ladisa, Lars E. Olson, Douglas Anthony Hettrick, David C. Warltier, Judy R. Kersten, Paul S. Pagel
Biomedical Engineering Faculty Research and Publications
Introduction
The success of vascular stents in the restoration of blood flow is limited by restenosis. Recent data generated from computational fluid dynamics (CFD) models suggest that the vascular geometry created by an implanted stent causes local alterations in wall shear stress (WSS) that are associated with neointimal hyperplasia (NH). Foreshortening is a potential limitation of stent design that may affect stent performance and the rate of restenosis. The angle created between axially aligned stent struts and the principal direction of blood flow varies with the degree to which the stent foreshortens after implantation.
Methods
In the current investigation, we …
Microfocal X-Ray Computed Tomography Post-Processing Operations For Optimizing Reconstruction Volumes Of Stented Arteries During 3d Computational Fluid Dynamics Modeling, John F. Ladisa, Lars E. Olson, Kristina M. Ropella, Robert C. Molthen, Steven Thomas Haworth, Judy R. Kersten, David C. Warltier, Paul S. Pagel
Microfocal X-Ray Computed Tomography Post-Processing Operations For Optimizing Reconstruction Volumes Of Stented Arteries During 3d Computational Fluid Dynamics Modeling, John F. Ladisa, Lars E. Olson, Kristina M. Ropella, Robert C. Molthen, Steven Thomas Haworth, Judy R. Kersten, David C. Warltier, Paul S. Pagel
Biomedical Engineering Faculty Research and Publications
Restenosis caused by neointimal hyperplasia (NH) remains an important clinical problem after stent implantation. Restenosis varies with stent geometry, and idealized computational fluid dynamics (CFD) models have indicated that geometric properties of the implanted stent may differentially influence NH. However, 3D studies capturing the in vivo flow domain within stented vessels have not been conducted at a resolution sufficient to detect subtle alterations in vascular geometry caused by the stent and the subsequent temporal development of NH. We present the details and limitations of a series of post-processing operations used in conjunction with microfocal X-ray CT imaging and reconstruction to …
Alterations In Wall Shear Stress Predict Sites Of Neointimal Hyperplasia After Stent Implantation In Rabbit Iliac Arteries, John F. Ladisa, Lars E. Olson, Robert C. Molthen, Douglas Anthony Hettrick, Phillip F. Pratt, Michael D. Hardel, Judy R. Kersten, David C. Warltier, Paul S. Pagel
Alterations In Wall Shear Stress Predict Sites Of Neointimal Hyperplasia After Stent Implantation In Rabbit Iliac Arteries, John F. Ladisa, Lars E. Olson, Robert C. Molthen, Douglas Anthony Hettrick, Phillip F. Pratt, Michael D. Hardel, Judy R. Kersten, David C. Warltier, Paul S. Pagel
Biomedical Engineering Faculty Research and Publications
Restenosis resulting from neointimal hyperplasia (NH) limits the effectiveness of intravascular stents. Rates of restenosis vary with stent geometry, but whether stents affect spatial and temporal distributions of wall shear stress (WSS) in vivo is unknown. We tested the hypothesis that alterations in spatial WSS after stent implantation predict sites of NH in rabbit iliac arteries. Antegrade iliac artery stent implantation was performed under angiography, and blood flow was measured before casting 14 or 21 days after implantation. Iliac artery blood flow domains were obtained from three-dimensional microfocal X-ray computed tomography imaging and reconstruction of the arterial casts. Indexes of …
Circumferential Vascular Deformation After Stent Implantation Alters Wall Shear Stress Evaluated With Time-Dependent 3d Computational Fluid Dynamics Models, John F. Ladisa, Lars E. Olson, Ismail Guler, Douglas Anthony Hettrick, Judy R. Kersten, David C. Warltier, Paul S. Pagel
Circumferential Vascular Deformation After Stent Implantation Alters Wall Shear Stress Evaluated With Time-Dependent 3d Computational Fluid Dynamics Models, John F. Ladisa, Lars E. Olson, Ismail Guler, Douglas Anthony Hettrick, Judy R. Kersten, David C. Warltier, Paul S. Pagel
Biomedical Engineering Faculty Research and Publications
The success of vascular stents in the restoration of blood flow is limited by restenosis. Recent data generated from computational fluid dynamics (CFD) models suggest that stent geometry may cause local alterations in wall shear stress (WSS) that have been associated with neointimal hyperplasia and subsequent restenosis. However, previous CFD studies have ignored histological evidence of vascular straightening between circumferential stent struts. We tested the hypothesis that consideration of stent-induced vascular deformation may more accurately predict alterations in indexes of WSS that may subsequently account for histological findings after stenting. We further tested the hypothesis that the severity of these …