Biomedical Engineering and Bioengineering Commons^™

Antegrade Iliac Artery Stent Implantation For The Temporal And Spatial Examination Of Stent-Induced Neointimal Hyperplasia And Alterations In Regional Fluid Dynamics, John F. Ladisa, Heidi T. Meier, Lars E. Olson, Judy R. Kersten, David C. Warltier, Paul S. Pagel

Biomedical Engineering Faculty Research and Publications

Neointimal hyperplasia remains an important problem after stent implantation. Previous investigations examining vascular responses to stent implantation and effects of drugs have used a retrograde deployment approach that may inadvertently alter the local fluid dynamics surrounding the stent. We present a model of antegrade iliac artery stent implantation that facilitates the analysis of stent-induced alterations in neointimal hyperplasia and wall shear stress in vivo. Methods: Stent delivery catheters were inserted through the left carotid artery in anesthetized rabbits (n=37). Catheters were advanced under fluoroscopic guidance to the distal iliac arteries, where the stent was deployed. Hemotoxylin and eosin …