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Biomedical Engineering and Bioengineering Commons™
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Articles 1 - 3 of 3
Full-Text Articles in Biomedical Engineering and Bioengineering
Alagebrium Inhibits Neointimal Hyperplasia And Restores Distributions Of Wall Shear Stress By Reducing Downstream Vascular Resistance In Obese And Diabetic Rats, Hongfeng Wang, Dorothee Weihrauch, Judy R. Kersten, Jeffrey M. Toth, Anthony G. Passerini, Anita Rajamani, Sonja Schrepfer, John F. Ladisa Jr.
Alagebrium Inhibits Neointimal Hyperplasia And Restores Distributions Of Wall Shear Stress By Reducing Downstream Vascular Resistance In Obese And Diabetic Rats, Hongfeng Wang, Dorothee Weihrauch, Judy R. Kersten, Jeffrey M. Toth, Anthony G. Passerini, Anita Rajamani, Sonja Schrepfer, John F. Ladisa Jr.
Biomedical Engineering Faculty Research and Publications
Mechanisms of restenosis in type 2 diabetes mellitus (T2DM) are incompletely elucidated, but advanced glycation end-products (AGEs)-induced vascular remodeling likely contributes. We tested the hypothesis that AGEs-related collagen cross-linking (ARCC) leads to increased downstream vascular resistance (DVR), and altered in-stent hemodynamics, thereby promoting neointimal hyperplasia (NH) in T2DM. We proposed that decreasing ARCC with ALT-711 (Alagebrium) would mitigate this response. Abdominal aortic stents were implanted in Zucker lean (ZL), obese (ZO), and diabetic (ZD) rats. Blood flow, vessel diameter, and wall shear stress (WSS) were calculated after 21 days, and NH was quantified. Arterial segments (aorta, carotid, iliac, femoral, arterioles) …
Identification Of Hemodynamically Optimal Coronary Stent Designs Based On Vessel Caliber, Timothy J. Gundert, Alison L. Marsden, Weiguang Yang, David S. Marks, John F. Ladisa
Identification Of Hemodynamically Optimal Coronary Stent Designs Based On Vessel Caliber, Timothy J. Gundert, Alison L. Marsden, Weiguang Yang, David S. Marks, John F. Ladisa
Biomedical Engineering Faculty Research and Publications
Coronary stent design influences local patterns of wall shear stress (WSS) that are associated with neointimal growth, restenosis, and the endothelialization of stent struts. The number of circumferentially repeating crowns NC for a given stent de- sign is often modified depending on the target vessel caliber, but the hemodynamic implications of altering NC have not previously been studied. In this investigation, we analyzed the relationship between vessel diameter and the hemodynamically optimal NC using a derivative-free optimization algorithm coupled with computational fluid dynamics. The algorithm computed the optimal vessel diameter, defined as minimizing the area of stent-induced …
Reactive Oxygen Species Modulate Coronary Wall Shear Stress And Endothelial Function During Hyperglycemia, Eric R. Gross, John F. Ladisa, Dorothee Weihrauch, Lars E. Olson, Tobias T. Kress, Douglas Anthony Hettrick, Paul S. Pagel, David C. Warltier, Judy R. Kersten
Reactive Oxygen Species Modulate Coronary Wall Shear Stress And Endothelial Function During Hyperglycemia, Eric R. Gross, John F. Ladisa, Dorothee Weihrauch, Lars E. Olson, Tobias T. Kress, Douglas Anthony Hettrick, Paul S. Pagel, David C. Warltier, Judy R. Kersten
Biomedical Engineering Faculty Research and Publications
Hyperglycemia is associated with generation of reactive oxygen species (ROS), and this action may contribute to accelerated atherogenesis. We tested the hypothesis that hyperglycemia produces alterations in left anterior descending coronary artery (LAD) wall shear stress concomitant with endothelial dysfunction and ROS production in dogs (n = 12) instrumented for measurement of LAD blood flow, velocity, and diameter. Dogs were randomly assigned to receive vehicle (0.9% saline) or the superoxide dismutase mimetic 4- hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (tempol) and were administered intravenous infusions of d-glucose to achieve target blood glucose concentrations of 350 and 600 mg/dl (moderate and severe hyperglycemia, respectively). Endothelial …