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Full-Text Articles in Biomedical Engineering and Bioengineering
Human Health Effects Assays, Ronald C. Sims, J. L. Sims, R. R. Dupont
Human Health Effects Assays, Ronald C. Sims, J. L. Sims, R. R. Dupont
Biological Engineering Faculty Publications
Environmental health risk assessments based upon animal study results, epidemiology, quantitative structure activity relationships (QSARs), dose-response relationships, risk perception, and expert systems approaches, and the evaluation of mechanisms of carcinogenesis represent the focus for 1987. The term "biological risk assessment" was discussed by Clayson1 to describe that part of risk assessment concerned with the relevance of specific animal results to the induction of human cancer. Guidelines for health assessment of suspect developmental toxicants addressed evaluation of data from animal testing studies.2 Animal toxicity data on 200 chemicals and epidemiologic data on 30 chemicals was included within a data …
Human Health Effects Assays, Ronald C. Sims, J. L. Sims, R. R. Dupont
Human Health Effects Assays, Ronald C. Sims, J. L. Sims, R. R. Dupont
Biological Engineering Faculty Publications
Health risk assessment of individual environmental chemicals, risks of drinking water supplies, methods for evaluating toxicity, and structure-activity relationships and response-surface methodology represent the focus for 1986. A report of the Steering Committee on Identification of Toxic and Potentially Toxic Chemicals for Consideration by the National Toxicology Pro gram found that, for the majority of substances they examined, data essential for human health hazard assessment were lacking.1 Milestone publications concerning human health effects aspects include works by Mortelmans et al,2 Busch et al,3 Hartman et al,4 Rein,5 Gentile,6 Hodgson,7 and Tagashira and Omura. …
Human Health Effects Assays, Ronald C. Sims, J. L. Sims, R. R. Dupont
Human Health Effects Assays, Ronald C. Sims, J. L. Sims, R. R. Dupont
Biological Engineering Faculty Publications
Discussion of the exponential increase in environmental toxicological information and an approach for organizing and using the information was presented by Lu and Wassom.1 A user's guide to the Registry of Toxic Effects of Chemical Substances (RTECS) was published by NIOSH2 that defines the record layouts and describes the types of data contained in the computer tape version of the 1984 Edition of the RTECS.3 A text summarizing information on approximately 800 toxic chemicals was edited by Sittig.4 Milestone publications concerning fundamentals of toxicology with environmental applications included the works of Gentile,5 Ashby,6 Mortel …
Human Health Effects Assays, Ronald C. Sims, J. L. Sims, R. R. Dupont
Human Health Effects Assays, Ronald C. Sims, J. L. Sims, R. R. Dupont
Biological Engineering Faculty Publications
Current development and use of short-term bioassays to evaluate potential human health hazards of environmental chemical exposure has been the focus of the U. S. Environmental Protection Agency (EPA) Second and Third Symposia on the Ap plication of Short-Term Bioassays in the Analysis of Complex Environmental Mixtures.1'2 Topics addressed included development and applications of bioassays, collection and preparation of environmental samples, characterization of hazardous components using bioassays, and environmental assessment. Bartsch and Tomabis,3 using six mutagenicity assays including sub mammalian and mammalian assays to evaluate the quantitative relationship between carcinogenicity and mutagenicity for 532 chemicals, concluded …