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Creep Response And Adhesion Dynamics Of Glioblastoma Multiforme Cells During Migration In Confined Environment, Ishan Kamal Khan

Bioengineering Dissertations

Glioblastoma multiforme (GBM) is the most common and malignant form of primary brain tumor. One of the major challenges facing the treatment of GBM tumors is the detachment and subsequent migration of peripheral cells. Migration of GBM cells take place in mechanically distinct confined microenvironment along the borders of white matter tracts. Studies using microfluidic devices mimicking the in-vivo microenvironment have shown that the migration characteristics are significantly altered with the change in kinematic state of the migrating cell. Several studies on different types of cells have consistently shown that a cancerous cell is more compliant than a normal cell …