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Full-Text Articles in Biomedical Engineering and Bioengineering
Observing P300 Amplitudes In Multiple Sensory Channels Using Cognitive Probing, Cody Lee Wintermute
Observing P300 Amplitudes In Multiple Sensory Channels Using Cognitive Probing, Cody Lee Wintermute
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High cognitive workload occurs when excessive working memory resources have been deployed to resolve sensory and cognitive processing, resulting in decremented task performance. The P300 event-related potential (ERP) component has shown sensitivity to cognitive load, and it was hypothesized that an attenuated P300 amplitude could be indicative of high cognitive load. We tested this hypothesis by having eight participants complete two continual performance tasks at increasing workload levels while simultaneously performing an oddball task, evoking P300 ERPs in either the auditory or tactile sensory channel. In our experiment, electroencephalographic recordings were collected over the parietal region to observe the P300 …
Kv2.1 Channel Clustering In The Sod1-G93a Mouse Model Of Als, Joshua Christopher Harris
Kv2.1 Channel Clustering In The Sod1-G93a Mouse Model Of Als, Joshua Christopher Harris
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Kv2.1 channels mediate slow-activating K+ rectifier current within the membrane of spinal motoneurons (MNs), and they are known to co-localize with other synapses and ion channels. Although Kv2.1 channels are suggested to regulate MN excitability, little research has gone into investigating its potential contribution to MN-altered excitability in Amyotrophic Lateral Sclerosis (ALS). Using the male SOD1-G93A mouse model of ALS, we examined Kv2.1 cluster area and density in lumbar MNs at four key stages of disease progression. In our experiments, MNs were separated by type via SK3 immunoreactivity in order to isolate and compare the responses of disease-resistant (slow; SK3+) …
Visual Sampling With The Eeg Alpha Oscillation, Kevin Eugene Alexander
Visual Sampling With The Eeg Alpha Oscillation, Kevin Eugene Alexander
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The posterior alpha rhythm, seen in human electroencephalograms (EEG), is posited to originate from cycling inhibitory/excitatory states of visual relay cells in the thalamus, which could result in discrete sampling of visual information. Here, we tested this hypothesis by presenting light flashes at perceptual threshold intensity through closed eyelids to 20 participants during times of spontaneous alpha oscillations. Alpha phase and amplitude were calculated relative to each individual’s retina-to-V1 conduction delay, estimated by the individuals’ C1 visual-evoked potential latency. Our results show that an additional 20.96% of stimuli are observed when afferenting at V1 during an alpha wave trough (272.41°) …