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Full-Text Articles in Biomedical Engineering and Bioengineering
Synthesis And Characterization Of Doxorubicin Carrying Cetuximab-Pamam Dendrimer Bioconjugates, Gunjan Saxena
Synthesis And Characterization Of Doxorubicin Carrying Cetuximab-Pamam Dendrimer Bioconjugates, Gunjan Saxena
Theses and Dissertations
A tumor targeted dendrimer based drug delivery system was designed and synthesized to carry chemotherapy drug doxorubicin. Polyamidoamine (PAMAM) dendrimer G4.5 was chosen as the underlying carrier. Anionic G4.5 is a good option for drug delivery as it consists of 128 surface groups, is less cytotoxic and favorably biodistributed. The delivery system was synthesized using a layer-by layer arrangement of three functional entities: chemotherapy drug doxorubicin, monoclonal antibody Cetuximab against EGF receptor, and polyethylene glycol (PEG). Doxorubicin was attached via an acid-sensitive hydrazon linkage to the dendrimer. Macromolecules are taken in by cells through endocytosis. pH inside the early endosomes …