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Virginia Commonwealth University

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VILI

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Full-Text Articles in Biomedical Engineering and Bioengineering

The Molecular And Mechanical Mechanisms Of The Age-Associated Increase In The Severity Of Experimental Ventilator Induced Lung Injury, Joseph Ames Herbert Jan 2016

The Molecular And Mechanical Mechanisms Of The Age-Associated Increase In The Severity Of Experimental Ventilator Induced Lung Injury, Joseph Ames Herbert

Theses and Dissertations

Abstract

Background

The majority of patients requiring mechanical ventilation are over the age of 65 and advanced age is known to increase the severity of ventilator-induced lung injury (VILI) and mortality. However, the mechanisms which predispose aging ventilator patients to increased mortality rates are not fully understood.

Pulmonary edema is a hallmark of VILI and the severity of edema increases with age. Ventilation with conservative fluid management decreases mortality rates in acute respiratory distress (ARDS) patients, but has not been investigated in VILI. We hypothesized that age-associated increases in pulmonary edema promote age-related increases in ventilator-associated mortality. Endoplasmic reticulum (ER) …


Providing Support For An Interdisciplinary Research Group With A Multidisciplinary Informationist Team: Is It Effective?, Margaret Henderson, Karen Gau, Julie A. Arendt, Martha Roseberry, John Cyrus Jan 2016

Providing Support For An Interdisciplinary Research Group With A Multidisciplinary Informationist Team: Is It Effective?, Margaret Henderson, Karen Gau, Julie A. Arendt, Martha Roseberry, John Cyrus

VCU Libraries Faculty and Staff Presentations

Background

Three subject librarians and a data librarian, representing three departments and two libraries at a university, were awarded an NLM Informationist Supplement to support an interdisciplinary Research Group with an NIH grant. The Informationist Team developed a model to utilize the skills of multiple librarians to support the increasing number of interdisciplinary and interprofessional research groups at the university. Librarians routinely attended lab meetings and shared notes with each other to monitor researcher needs.

Methods

The Informationist Team regularly provided support for literature searches, creating search alerts, bibliographic citation management and sharing, and data management to an interdisciplinary Research …