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Full-Text Articles in Biomedical Engineering and Bioengineering

Effects Of Seat And Axle Position On Pain, Pathology, And Independence In Pediatric Manual Wheelchair Users With Spinal Cord Injury, Hannah Frank Dec 2021

Effects Of Seat And Axle Position On Pain, Pathology, And Independence In Pediatric Manual Wheelchair Users With Spinal Cord Injury, Hannah Frank

Theses and Dissertations

Manual wheelchair (MWC) users with spinal cord injury (SCI) rely heavily on their upperextremities to complete daily occupations. Due to repetitive shoulder use during wheelchair mobility and propulsion, MWC users are at greater risk of shoulder pain and shoulder pathology, and thus decreased independence, and lower quality of life. The relative fit of the wheelchair and its parameters are critical and can further impact the user’s propulsion biomechanics. Parameters such as seat angle and axle position may put the user in detrimental shoulder positions for longer periods of time, impacting health outcomes even more. Although the effects of wheelchair setup …


Medical Image Segmentation Using Machine Learning, Masoud Khani Aug 2021

Medical Image Segmentation Using Machine Learning, Masoud Khani

Theses and Dissertations

Image segmentation is the most crucial step in image processing and analysis. It can divide an image into meaningfully descriptive components or pathological structures. The result of the image division helps analyze images and classify objects. Therefore, getting the most accurate segmented image is essential, especially in medical images. Segmentation methods can be divided into three categories: manual, semiautomatic, and automatic. Manual is the most general and straightforward approach. Manual segmentation is not only time-consuming but also is imprecise. However, automatic image segmentation techniques, such as thresholding and edge detection, are not accurate in the presence of artifacts like noise …


Development Of A 7 Dof Exoskeleton Robot For Rehabilitation Of Lower Extremity, Sk Hasan Aug 2021

Development Of A 7 Dof Exoskeleton Robot For Rehabilitation Of Lower Extremity, Sk Hasan

Theses and Dissertations

The World Health Organization reports that worldwide about 1 billion people have some form ofdisability. Of these, 110-190 million people have significant difficulties in functioning (mainly upper and lower extremity disability) independently. The major causes of human lower extremity disability include stroke, trauma, spinal cord injuries, and muscular dystrophy. Every 40 seconds, someone in the United States has a stroke. A statistic shows that approximately 65% of post-stroke patients suffer lower extremity impairment. Rehabilitation programs are the main method to promote functional recovery in disabled individuals. The conventional therapeutic approach requires a long commitment from a therapist or a clinician. …


Developing Optical Imaging Tools To Investigate Metabolic And Structural Biomarkers In Rodent Injury Models, Soudeh Mostaghimi May 2021

Developing Optical Imaging Tools To Investigate Metabolic And Structural Biomarkers In Rodent Injury Models, Soudeh Mostaghimi

Theses and Dissertations

Optical fluorescence imaging is one of the vastly growing fields of imaging used in a broad variety of preclinical investigation with great interest in translating its principles into clinical applications. Optical fluorescence imaging provides images of functional and structural changes with cellular and subcellular resolution in tissues at a low-cost. This technique takes advantage of the absorption of light photons at a specific wavelength by intrinsic or extrinsic fluorophores and emission of photons at characteristic wavelengths. The characteristics of the emitted wavelengths such as their energy and illuminance give substantial information of the imaged tissue. In the research presented here, …


Fabrication Of Double-Walled Polymeric Microspheres For Improved Bone Healing And Regeneration., Sara Travia May 2021

Fabrication Of Double-Walled Polymeric Microspheres For Improved Bone Healing And Regeneration., Sara Travia

Theses and Dissertations

The purpose of this study was to fabricate double-walled microspheres loaded with specific drugs to improve bone healing properties. The proposed microsphere design consists of hydroxyapatite-loaded poly(L-lactic acid) (PLLA) as the core layer and cobalt (II) chloride-loaded poly(DL-lactic–co-glycolic) (PLGA) as the shell layer. Cobalt (II) chloride and hydroxyapatite were the chosen drugs because they have previously shown to aid chondrogenesis and osteogenesis, respectively. The morphology, layer identification, and elemental composition of the prepared microspheres were evaluated using a combination of scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), 3D laser microscope, and selective dissolution techniques. With the help of …