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Biomedical Engineering and Bioengineering Commons™
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- Discipline
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- Biomaterials (3)
- Bioimaging and Biomedical Optics (2)
- Chemical Engineering (2)
- Amino Acids, Peptides, and Proteins (1)
- Analytical Chemistry (1)
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- Biochemical and Biomolecular Engineering (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Biological Engineering (1)
- Biomedical Devices and Instrumentation (1)
- Chemicals and Drugs (1)
- Chemistry (1)
- Life Sciences (1)
- Materials Chemistry (1)
- Medicine and Health Sciences (1)
- Membrane Science (1)
- Molecular, Cellular, and Tissue Engineering (1)
- Nanoscience and Nanotechnology (1)
- Organic Chemistry (1)
- Other Chemical Engineering (1)
- Other Chemicals and Drugs (1)
- Physical Sciences and Mathematics (1)
- Polymer Chemistry (1)
- Polymer Science (1)
- Structural Biology (1)
- Keyword
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- Cancer (1)
- Cancer metastasis (1)
- Channels in PEG hydrogels (1)
- Electromechanical characterization (1)
- Hydrogel (1)
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- Hydrophobic tagging (1)
- Immunotherapy (1)
- Inflammation (1)
- Lipid bilayer (1)
- Lipid physicochemical properties (1)
- Macrophage (1)
- Macroscale Drug Delivery (MDD) (1)
- Michael acceptors (1)
- Model biomembrane (1)
- PEG Maleimide hydrogels (1)
- Protein labeling (1)
- Supramolecules (1)
- Targeted Protein Degradation (TPD) (1)
- Tissue engineering (1)
- Tissue mimicking gels (1)
- Publication
Articles 1 - 4 of 4
Full-Text Articles in Biomedical Engineering and Bioengineering
Reactive Chemistries For Protein Labeling, Degradation, And Stimuli Responsive Delivery, Myrat Kurbanov
Reactive Chemistries For Protein Labeling, Degradation, And Stimuli Responsive Delivery, Myrat Kurbanov
Doctoral Dissertations
Reactive chemistries for protein chemical modification play an instrumental role in chemical biology, proteomics, and therapeutics. Depending on the application, the selectivity of these modifications can range from precise modification of an amino acid sequence by genetic manipulation of protein expression machinery to a stochastic modification of lysine residues on the protein surface. Ligand-Directed (LD) chemistry is one of the few methods for targeted modification of endogenous proteins without genetic engineering. However, current LD strategies are limited by stringent amino acid selectivity. To bridge this gap, this thesis focuses on the development of highly reactive LD Triggerable Michael Acceptors (LD-TMAcs) …
Optimizing Channel Formation In Peg Maleimide Hydrogels, Bakthavachalam Kannadasan
Optimizing Channel Formation In Peg Maleimide Hydrogels, Bakthavachalam Kannadasan
Masters Theses
Blood vessels including the arteries, veins, and capillaries are a critical and indispensable component of various organisms. Some studies estimate that if all the blood vessels present in our body are arranged in line, they would amount to a total length of approximately 60,000 miles. This distance is enough to circle the world two and a half times! In addition to being all pervasive, blood vessels perform certain key functions such as delivery of oxygen and nutrients to various tissues in the body. They also assist in the spread of diseases such as cancer. Therefore, it is important to study …
Electrostatic Effects On Lipid Bilayer Physicochemal Properties And Vesicle Adhesion, Oscar Zabala-Ferrera
Electrostatic Effects On Lipid Bilayer Physicochemal Properties And Vesicle Adhesion, Oscar Zabala-Ferrera
Doctoral Dissertations
Lipids are an integral part of cells, being the principal component of the cell membrane, and contributing to the function and regulation of biological processes. Lipid nanoparticles mimicking a cell’s endosomes or exosomes are of particular interest within the pharmaceutical industry for their ability to deliver cargo such as RNA into target cells. The delivery process faces a multitude of challenges, so a rational design approach for vesicles that considers a lipid’s physicochemical contribution to the membrane is desired. To that end, this thesis explores the creation of large area biomembranes along with the development of electromechanical and optical characterization …
Reprogramming And Imaging Of Tumor Associated Macrophages Using Spuramolecular Nanoparticles, Anujan Ramesh
Reprogramming And Imaging Of Tumor Associated Macrophages Using Spuramolecular Nanoparticles, Anujan Ramesh
Doctoral Dissertations
Macrophages are highly plastic cells that are a part of the mononuclear phagocytic system and play a crucial role in both the innate and the adaptive immune systems. Although they have functionally diverse roles involved in physiological and pathological processes, they primarily act as phagocytes that aid in clearing infections. During these instances of tissue injury or infections, circulating monocytes are recruited to the site of the injury, where they differentiate to give rise to macrophages that have a pro-inflammatory function. These monocytes derived macrophages, however, exist across a spectrum of phenotypes based on the local tissue environment. The two …