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Full-Text Articles in Biomedical Engineering and Bioengineering
Nanotechnology Overview Powerpoint, Mark Tuominen
Nanotechnology Overview Powerpoint, Mark Tuominen
Nanotechnology Teacher Summer Institutes
Nanotechnology is the understanding and control of matter at dimensions of roughly 1 to 100 nanometers, where unique phenomena enable novel applications. This PowerPoint gives an overview of the field and introduces the teacher summer institute.
Identification Of A New Class Of Antifungals Targeting The Synthesis Of Fungal Sphingolipids, Patrick Flaherty, Et. Al.
Identification Of A New Class Of Antifungals Targeting The Synthesis Of Fungal Sphingolipids, Patrick Flaherty, Et. Al.
Mathematics and Statistics Department Faculty Publication Series
Recent estimates suggest that>300 million people are afflicted by serious fungal infections worldwide. Current antifungal drugs are static and toxic and/or have a narrow spectrum of activity. Thus, there is an urgent need for the development of new antifungal drugs. The fungal sphingolipid glucosylceramide (GlcCer) is critical in promoting virulence of a variety of human-pathogenic fungi. In this study, we screened a synthetic drug library for compounds that target the synthesis of fungal, but not mammalian, GlcCer and found two compounds [N=-(3-bromo-4-hydroxybenzylidene)-2-methylbenzohydrazide (BHBM) and its derivative, 3-bromo-N=-(3-bromo-4-hydroxybenzylidene) benzohydrazide (D0)] that were highly effective in vitro and in vivo against …