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Full-Text Articles in Biomedical Engineering and Bioengineering
Development And Evaluation Of A Modeling Platform For Evaluating Immunotherapeutic Efficacy In The Tumor Microenvironment., Dylan Andrew Goodin
Development And Evaluation Of A Modeling Platform For Evaluating Immunotherapeutic Efficacy In The Tumor Microenvironment., Dylan Andrew Goodin
Electronic Theses and Dissertations
The tumor microenvironment (TME) represents the complex outcome of numerous tumor, stromal, and immune interactions, and whose composition can significantly affect treatment response. Particularly, immunotherapeutic efficacy is subject to multiple tumor-specific TME interactions that may be difficult to evaluate/predict clinically. Mathematical modelling has been formulated to evaluate specific aspects of the TME, including vasculature, ECM deposition, and immune-tumor interactions. However, the computational challenge of simulating multiple TME interactions has led to sacrificing varying degrees of model generalizability and clinical relevance. This work describes increased computational performance of a 3D continuum model that simulates tumor tissue, ECM, and vasculature using a …
A Modeling Platform To Predict Cancer Survival And Therapy Outcomes Using Tumor Tissue Derived Metabolomics Data., Hunter Allan Miller
A Modeling Platform To Predict Cancer Survival And Therapy Outcomes Using Tumor Tissue Derived Metabolomics Data., Hunter Allan Miller
Electronic Theses and Dissertations
Cancer is a complex and broad disease that is challenging to treat, partially due to the vast molecular heterogeneity among patients even within the same subtype. Currently, no reliable method exists to determine which potential first-line therapy would be most effective for a specific patient, as randomized clinical trials have concluded that no single regimen may be significantly more effective than others. One ongoing challenge in the field of oncology is the search for personalization of cancer treatment based on patient data. With an interdisciplinary approach, we show that tumor-tissue derived metabolomics data is capable of predicting clinical response to …
Examining The Effects Of Macrophage Populations On Cancerous Tumor Growth., Grace E. Mahlbacher
Examining The Effects Of Macrophage Populations On Cancerous Tumor Growth., Grace E. Mahlbacher
Electronic Theses and Dissertations
The most abundant immune cell types of the tumor microenvironment macrophages recruited there by tumor-eluted factors. The role of these immune cells in tumor progression, and the interplay between tumor and immune cells is an emerging field of research with potential for novel treatment strategies. Here, a TIE2 expressing macrophage (TEM) subtype is integrated into a virtual tumor model. Within the 2D microenvironment, the TEM will differentiate from an extravasated monocyte precursor, congregate around the abluminal side of the vasculature in response to a chemoattractant gradient, secrete cytokines which favor differentiation of a separate angiogenic macrophage subtype [1]. The effects …