Biomedical Engineering and Bioengineering Commons^™

Validation Of Computational Fluid Dynamic Simulations Of Membrane Artificial Lungs With X-Ray Imaging, Cameron Christopher Jones

Theses and Dissertations--Biomedical Engineering

The functional performance of membrane oxygenators is directly related to the perfusion dynamics of blood flow through the fiber bundle. Non-uniform flow and design characteristics can limit gas exchange efficiency and influence susceptibility of thrombus development in the fiber membrane. Computational fluid dynamics (CFD) is a powerful tool for predicting properties of the flow field based on prescribed geometrical domains and boundary conditions. Validation of numerical results in membrane oxygenators has been predominantly based on experimental pressure measurements with little emphasis placed on confirmation of the velocity fields due to opacity of the fiber membrane and limitations of optical velocimetric …