Biomedical Engineering and Bioengineering Commons^™

Correlating The Magnitude And Spatial Gradient Of Alternans, Stuart Traxel

University of Kentucky Master's Theses

Electrical restitution has been shown to inaccurately predict the occurrence of alternans of action potential duration. A new method using the spatial gradient of alternans (SGA) is proposed to predict alternans and cardiac electrical stability. A simulated 1-D strand of tissue was used to compare indexes computed from restitution methods and the SGA method to changes in the amplitude of alternans using different electro-physiological alterations. The SGA method correlated better with changes in the amplitude of alternans than restitution methods for a decrease in the transient outward current (I_to) and conduction velocity. Restitution methods correlated better with changes …