Open Access. Powered by Scholars. Published by Universities.®
Biomedical Engineering and Bioengineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Biomedical Engineering and Bioengineering
The Utilization Of Autofluorescence To Study The Effects Of L-Buthionine-Sulfoximine On Cellular Metabolism In Vitro, Madison Belew
The Utilization Of Autofluorescence To Study The Effects Of L-Buthionine-Sulfoximine On Cellular Metabolism In Vitro, Madison Belew
Biomedical Engineering Undergraduate Honors Theses
Oxidative damage and stress impacts metabolic activity and has been implicated in a number of diseases . These medical conditions have been found to be associated with a lack of glutathione (GSH). There is a need to study the effects that the absence of glutathione has in order to expand knowledge of indicators that cause conditions like cataracts, cancer, or impaired wound healing. L-buthionine-sulfoximine (BSO) has been used in past studies to hinder GSH production and induce oxidative stress within a cell. This study explores the effects of BSO and induced oxidative stress on the metabolic activity and processes within …
Optical Metabolic Imaging As A Predictor Of Patient Tumor Response To Therapy And Apoptosis, Andrew Larey
Optical Metabolic Imaging As A Predictor Of Patient Tumor Response To Therapy And Apoptosis, Andrew Larey
Biomedical Engineering Undergraduate Honors Theses
Despite a plethora of medical advancements, malignant tumors remain difficult to treat due to complex cancer biology and interpatient heterogeneity. Phenotypically similar tumors may respond differently to a given treatment. In clinical oncology, it is paramount to quantify tumor response to therapy for predicting treatment outcome, monitoring tumor changes, identifying effective therapies, and avoiding unnecessary cost and toxicity to the patient. Current standards of monitoring tumor response to therapy include CT, MRI, PET, and histopathology; these methods either take a merely anatomical approach or are invasive and time consuming, necessitating a functional biomarker approach. MPM represents a metabolic-level method of …