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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Kinematic Analysis Of Spinal Cord Injury Animals Treated With A Neurotrophin-Infused Scaffold And Body Weight Supported Treadmill Training, Alexander Herman
Kinematic Analysis Of Spinal Cord Injury Animals Treated With A Neurotrophin-Infused Scaffold And Body Weight Supported Treadmill Training, Alexander Herman
Theses and Dissertations
Spinal Cord Injury (SCI) is a condition that affects around 250,000 Americans with no cure. Existing treatments rely on physical therapies such as body weight support treadmill training (BWSTT). Treatments currently being researched include the use of implantable cells and biomaterials. Our study investigated the changes in locomotive gait and range of motion via a combinational treatment using a bioengineered scaffold [poly (N-isopropyl acrylamide) polyethylene glycol (PNIPAAm-g-PEG) with BDNF and NT-3] and rehabilitation training using BWSTT in a clinically relevant contusion SCI animal model. Five different groups of animals (Sham, Injury, BWSTT, Implant, and Combinational) were tested on a treadmill …
Effects Of Passive And Active Training Paradigms On Bone And Muscle Recovery After Spinal Cord Injury, Brittany Lynn King
Effects Of Passive And Active Training Paradigms On Bone And Muscle Recovery After Spinal Cord Injury, Brittany Lynn King
Theses and Dissertations
The effects spinal cord injury (SCI) has have been studied in both human and animal models. Specifically in incomplete SCI, the bone degradation and muscle atrophy seen in the lower limbs has been documented, along with the effects of different training paradigms on bone and muscle loss. This study implemented a clinically relevant animal model of a moderate spinal contusion injury at the T9--T10 level, along with active body weight supported treadmill training (BWSTT) and passive bike training, to compare the effects such training methods have on the bone microstructure properties and muscle masses in the lower limbs of rats. …
Effects Of Bioengineering Scaffolds Releasing Neurotrophins And Body Weight Supported Treadmill Training On H-Reflex After Spinal Cord Injury, Jaclyn Ann Witko
Effects Of Bioengineering Scaffolds Releasing Neurotrophins And Body Weight Supported Treadmill Training On H-Reflex After Spinal Cord Injury, Jaclyn Ann Witko
Theses and Dissertations
Changes in monosynaptic reflex, often used to study spasticity, has been tested through the H-reflex in spinal cord injury (SCI) patients after rehabilitation training, such as body weight support treadmill training or cycling. The combinational effects of rehabilitation training and a bioengineered scaffold on spasticity in SCI animal model have not been studied. We used a clinically relevant animal model of spinal cord moderate contusion at T9/T10 with BWSTT and the bioengineered scaffold PNIPAAm-g-PEG loaded with the growth factors BDNF/NT-3 to measure the efficiency of the combinational bioengineered approach to treat spasticity. Five animal groups were included in the study: …