Biomedical Engineering and Bioengineering Commons^™

Self-Healing Properties Of Augmented Injectable Hydrogels Over Time, Connor Castro, Zachary R. Brown, Erik Brewer

Henry M. Rowan College of Engineering Faculty Scholarship

Injectable polymers offer great benefits compared to other types of implants; however, they tend to suffer from increased mechanical wear and may need a replacement implant to restore these mechanical properties. The purpose of this experiment is to investigate an injectable hydrogel's self-healing ability to augment itself to a previously molded implant. This was accomplished by performing a tensile strength test to examine potential diminishing mechanical properties with increasing time, as well as dye penetration tests to examine the formation of interfacial bonds between healed areas of hydrogels. There were several time points in between injections that were explored, from …

Controlled Release Of Multiple Therapeutics From Silicone Hydrogel Contact Lenses For Post-Cataract/Post-Refractive Surgery And Uveitis Treatment., Stephen A Dipasquale, Biaggio Uricoli, Matthew C Dicerbo, Thea L Brown, Mark Byrne

Henry M. Rowan College of Engineering Faculty Scholarship

PURPOSE: This work demonstrates seven-day controlled and extended in vitro physiological flow dual release of multiple post-ocular surgery therapeutics from extended-wear contact lenses as a dropless alternative for treatment of uveitis and corneal inflammation, pain, and infection. Lens replacement each week optimizes treatment matching patient recall time with the ability to increase or decrease dosage.

METHODS: Lenses were synthesized using molecular imprinting to create lenses with macromolecular memory for diclofenac sodium (DS) and dexamethasone sodium phosphate (DMSP), as well as bromfenac sodium (BS) and moxifloxacin (MOX). Drug uptake and release were analyzed, and physical properties were measured and compared to …