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Full-Text Articles in Biomedical Engineering and Bioengineering
Thin-Film Sol-Gel As Controlled Delivery Platform For Neural Microelectrodes, Margaret A. Harden, Matthew D. Mcdermott, Kevin J. Otto
Thin-Film Sol-Gel As Controlled Delivery Platform For Neural Microelectrodes, Margaret A. Harden, Matthew D. Mcdermott, Kevin J. Otto
The Summer Undergraduate Research Fellowship (SURF) Symposium
Long-term efficacy of neural implantation devices is a persisting challenge in neural engineering and rehabilitation. Upon implantation of a neural device, the foreign body response (FBR) is triggered and glial cells form a sheath around the electrode array. This sheath isolates the array from the rest of the brain both mechanically and electrically. Tetramethyl orthosilicate (TMOS), a thin-film polymer, has been shown to not negatively impact the impedance and charge-carrying capacity, as well as offer a controlled delivery method to deliver pharmaceuticals to mitigate inflammation without significant effect to device design. Using an in vitro protein delivery model to analyze …
Quantification Of Lps Eluate From Coated Microelectrode Devices, Jahrane A. Dale, Janak Gaire, Kevin J. Otto
Quantification Of Lps Eluate From Coated Microelectrode Devices, Jahrane A. Dale, Janak Gaire, Kevin J. Otto
The Summer Undergraduate Research Fellowship (SURF) Symposium
Penetrating microelectrode arrays have a great potential to be used as control and communication interfaces for neuroprosthetics. A persistent obstacle in the clinical implementation of microelectrode arrays is the chronic degradation of these devices, putatively due to the foreign body response. Though researchers have studied the progression of the foreign body response and the effect of anti-inflammatory drugs on the efficacy of the implant, the exact biological mechanisms of implant degradation are not fully understood. To more closely investigate the effect of the foreign body response on device degradation, neuroinflammation can be exacerbated by coating dummy electrodes implanted into mice …