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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Beyond Biobricks: Synthesizing Synergistic Biochemical Systems From The Bottom-Up, Mark A. Bedau
Beyond Biobricks: Synthesizing Synergistic Biochemical Systems From The Bottom-Up, Mark A. Bedau
Systems Science Friday Noon Seminar Series
Engineers who attempt to discover and optimize the behavior of complex biochemical systems face a dauntingly difficult task. This is especially true if the systems are governed by multiple qualitative and quantitative variables that have non-linear response functions and that interact synergistically. The synthetic biology community has responded to this difficulty by promoting the use of "standard biological parts" called "BioBricks", which are supposed to make biology into traditional engineering and enable engineers to "program living organisms in the same way a computer scientists can program a computer". But the BioBricks research program faces daunting hurdles, because the nonlinearity and …
Assessing The Prediction Potential Of An In Silico Computer Model Of Intracranial Pressure Dynamics, Wayne Wakeland, Rachel Agbeko, Kevin Vinecore, Mark Peters, Brahm Goldstein
Assessing The Prediction Potential Of An In Silico Computer Model Of Intracranial Pressure Dynamics, Wayne Wakeland, Rachel Agbeko, Kevin Vinecore, Mark Peters, Brahm Goldstein
Systems Science Faculty Publications and Presentations
Objective: Traumatic brain injury (TBI) frequently results in poor outcome, suggesting that new approaches are needed. We hypothesized that a patient-specific in silico computer model of intracranial pressure (ICP) dynamics may predict the ICP response to therapy.
Design: In silico model analysis of prospectively collected data.
Setting: Twenty-three and 16-bed pediatric intensive care units in two tertiary care academic hospitals.
Patients: Nine subjects with severe TBI undergoing ICP monitoring (7 M/2 F, age range 3-17 years).
Interventions: Random changes in head-of-bed (HOB) (0[degrees], 10[degrees], 20[degrees], 30[degrees], 40[degrees]) elevation and respiratory rate (to achieve a [DELTA]ETco2 = +/-3-4 mm Hg) were …