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Biomedical Engineering and Bioengineering Commons™
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Articles 1 - 7 of 7
Full-Text Articles in Biomedical Engineering and Bioengineering
Incorporating Germanium Oxide Into The Glass Phase Of Novel Zinc/Magnesium-Based Gpcs Designed For Bone Void Filling: Evaluating Their Physical And Mechanical Properties, Basel A. Khader, Omar Rodriguez, Mark R. Towler
Incorporating Germanium Oxide Into The Glass Phase Of Novel Zinc/Magnesium-Based Gpcs Designed For Bone Void Filling: Evaluating Their Physical And Mechanical Properties, Basel A. Khader, Omar Rodriguez, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
The structural role of Germanium (Ge), when substituting for Zinc (Zn) up to 8 mol % in the 0.48SiO2-0.12CaO-0.36ZnO-0.04MgO glass series, was investigated with respect to both the glass chemistry and also the properties of glass polyalkenoate cements (GPCs) manufactured from them. The Network connectivity (NC) of the glass was calculated to increase from 1.83 to 2.42 with the addition of GeO2 (0-8 mol %). Differential thermal analysis (DTA) results confirmed an increase in the glass transition temperature (Tg) of the glass series with GeO2 content. X-ray photoelectron spectroscopy (XPS) showed an increase in …
Development Of A Novel Bioactive Glass Suitable For Osteosarcoma-Related Bone Grafts, Alireza Rahimnejad Yazdi, Lawrence Torkan, Stephen D. Waldman, Mark R. Towler
Development Of A Novel Bioactive Glass Suitable For Osteosarcoma-Related Bone Grafts, Alireza Rahimnejad Yazdi, Lawrence Torkan, Stephen D. Waldman, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
In this study, zinc borate-based glasses with increasing gallium content (0, 2.5, 5, 10, and 15 wt % Ga) were synthesized and their effect on the viability and proliferation of preosteoblasts and osteosarcoma cancer cells were investigated. Methyl thiazolyl tetrazolium (MTT) cell viability assays using glass degradation extracts revealed that the extracts from glasses with lower Ga contents could enhance the viability of preosteoblasts, while extracts from the glass composition with 15 wt % Ga caused statistically significant reduction of their viability. MTT cell viability assays using the extracts and osteosarcoma cells showed that only extracts from the glass composition …
Injectable Glass Polyalkenoate Cements: Evaluation Of Their Rheological And Mechanical Properties With And Without The Incorporation Of Lidocaine Hydrochloride, P. Niranjan, A. Alhalawani, S. Phull, I. Beniluz, B. Krishnan, P. Zalzal, Mark R. Towler
Injectable Glass Polyalkenoate Cements: Evaluation Of Their Rheological And Mechanical Properties With And Without The Incorporation Of Lidocaine Hydrochloride, P. Niranjan, A. Alhalawani, S. Phull, I. Beniluz, B. Krishnan, P. Zalzal, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
Lidocaine hydrochloride is used as an anesthetic in many clinical applications. This short communication investigates the effect of complete substitution of lidocaine hydrochloride for deionized (DI) water on the physico-chemical properties of two novel glass polyalkenoate cements. Substituting DI water with lidocaine hydrochloride resulted in cements with shorter working times but comparable setting times and mechanical properties. Fourier transform infrared spectroscopy confirmed that the setting reaction in cements containing DI water and lidocaine hydrochloride was completed within 24 h, post cement preparation and maturation. Further, it was explained that lidocaine hydrochloride binds to poly(acrylic) acid (PAA) due to electrostatic forces …
The Effect Of Mg²⁺ Incorporation Into The Glass Phase Of Zinc-Based Glass Polyalkenoate Cements, Basel A. Khader, Omar Rodriguez, Mark R. Towler
The Effect Of Mg²⁺ Incorporation Into The Glass Phase Of Zinc-Based Glass Polyalkenoate Cements, Basel A. Khader, Omar Rodriguez, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
The suitability of glass polyalkenoate cements (GPCs) as injectable adhesives in orthopedics have been compromised by the presence of aluminum (Al), a component in the glass phase of all commercial GPCs. There has been considerable work on the development of Al-free GPCs which can be formulated based on calcium (Ca) zinc (Zn) silicate (Si) glasses. These materials, in terms of biocompatibility and mechanical properties, have potential for orthopedics. However, many of these experimental Al-free GPCs have setting times shorter than 60 s, restricting clinical applications. Here, the authors incorporate Magnesium (Mg) into the glass phase of Al-free GPCs in an …
Raman Spectroscopy Predicts The Link Between Claw Keratin And Bone Collagen Structure In A Rodent Model Of Oestrogen Deficiency, M. Clare Caraher, Antonia Sophocleous, J. Renwick Beattie, Olive O'Driscoll, Niamh M. Cummins, Orlaith Brennan, Fergal J. O'Brien, Stuart H. Ralston, Steven E.J. Bell, Mark R. Towler, Aymen I. Idris
Raman Spectroscopy Predicts The Link Between Claw Keratin And Bone Collagen Structure In A Rodent Model Of Oestrogen Deficiency, M. Clare Caraher, Antonia Sophocleous, J. Renwick Beattie, Olive O'Driscoll, Niamh M. Cummins, Orlaith Brennan, Fergal J. O'Brien, Stuart H. Ralston, Steven E.J. Bell, Mark R. Towler, Aymen I. Idris
Chemical and Biochemical Engineering Faculty Research & Creative Works
Osteoporosis is a common disease characterized by reduced bone mass and an increased risk of fragility fractures. Low bone mineral density is known to significantly increase the risk of osteoporotic fractures; however, the majority of non-traumatic fractures occur in individuals with a bone mineral density too high to be classified as osteoporotic. Therefore, there is an urgent need to investigate aspects of bone health, other than bone mass, that can predict the risk of fracture. Here, we successfully predicted association between bone collagen and nail keratin in relation to bone loss due to oestrogen deficiency using Raman spectroscopy. Raman signal …
The Impact Of Gallium Content On Degradation, Bioactivity, And Antibacterial Potency Of Zinc Borate Bioactive Glass, Alireza Rahimnejad Yazdi, Lawrence Torkan, Wendy Stone, Mark R. Towler
The Impact Of Gallium Content On Degradation, Bioactivity, And Antibacterial Potency Of Zinc Borate Bioactive Glass, Alireza Rahimnejad Yazdi, Lawrence Torkan, Wendy Stone, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
Zinc borate glasses with increasing gallium content (0, 2.5, 5, 10, and 15 Wt % Ga) were synthesized and their degradation, bioactivity in simulated body fluid (SBF), and antibacterial properties were investigated. ICP measurements showed that increased gallium content in the glass resulted in increased gallium ion release and decreased release of other ions. Degradability declined with the addition of gallium, indicating the formation of more symmetric BO3 units with three bridging oxygens and asymmetric BO3 units with two bridging oxygens in the glass network as the gallium content in the series increased. The formation of amorphous Ca-P …
A Preliminary Evaluation Of The Ability Of Keratotic Tissue To Act As A Prognostic Indicator Of Hip Fracture Risk, J. Renwick Beattie, Diane Feskanich, M. Clare Caraher, Mark R. Towler
A Preliminary Evaluation Of The Ability Of Keratotic Tissue To Act As A Prognostic Indicator Of Hip Fracture Risk, J. Renwick Beattie, Diane Feskanich, M. Clare Caraher, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
Studies have shown that Raman spectroscopic analysis of fingernail clippings can help differentiate between post-menopausal women who have and who have not suffered a fracture. However, all studies to date have been retrospective in nature, comparing the proteins in nails sourced from women, post-fracture. The objective of this study was to investigate the potential of a prospective test for hip fracture based on spectroscopic analysis of nail tissue. Archived toenail samples from post-menopausal women aged 50 to 63 years in the Nurses' Health Study were obtained and analysed by Raman spectroscopy. Nails were matched case-controls sourced from 161 women; 82 …