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Full-Text Articles in Biomedical Engineering and Bioengineering
Vascular Injury After Whole Thoracic X-Ray Irradiation In The Rat, S. N. Ghosh, Q. Wu, M. Mäder, B. L. Fish, John E. Moulder, Elizabeth R. Jacobs, Meetha Medhora, Robert C. Molthen
Vascular Injury After Whole Thoracic X-Ray Irradiation In The Rat, S. N. Ghosh, Q. Wu, M. Mäder, B. L. Fish, John E. Moulder, Elizabeth R. Jacobs, Meetha Medhora, Robert C. Molthen
Biomedical Engineering Faculty Research and Publications
Purpose
To study vascular injury after whole thoracic irradiation with single sublethal doses of X-rays in the rat and to develop markers that might predict the severity of injury.
Methods and Materials
Rats that received 5- or 10-Gy thorax-only irradiation and age-matched controls were studied at 3 days, 2 weeks, and 1, 2, 5, and 12 months. Several pulmonary vascular parameters were evaluated, including hemodynamics, vessel density, total lung angiotensin-converting enzyme activity, and right ventricular hypertrophy.
Results
By 1 month, the rats in the 10-Gy group had pulmonary vascular dropout, right ventricular hypertrophy, increased pulmonary vascular resistance, increased dry lung …