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Micro-Ct Image-Derived Metrics Quantify Arterial Wall Distensibility Reduction In A Rat Model Of Pulmonary Hypertension, Roger H. Johnson, Kelly L. Karau, Robert C. Molthen, Steven Thomas Haworth, Christopher A. Dawson

Biomedical Engineering Faculty Research and Publications

We developed methods to quantify arterial structural and mechanical properties in excised rat lungs and applied them to investigate the distensibility decrease accompanying chronic hypoxia-induced pulmonary hypertension. Lungs of control and hypertensive (three weeks 11% O₂) animals were excised and a contrast agent introduced before micro-CT imaging with a special purpose scanner. For each lung, four 3D image data sets were obtained, each at a different intra-arterial contrast agent pressure. Vessel segment diameters and lengths were measured at all levels in the arterial tree hierarchy, and these data used to generate features sensitive to distensibility changes. Results indicate …