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Full-Text Articles in Biomedical Engineering and Bioengineering
Multimodal Sensory Integration For Perception And Action In High Functioning Children With Autism Spectrum Disorder, Nicole Marie Gregor Salowitz
Multimodal Sensory Integration For Perception And Action In High Functioning Children With Autism Spectrum Disorder, Nicole Marie Gregor Salowitz
Dissertations (1934 -)
Movement disorders are the earliest observed features of autism spectrum disorder (ASD) present in infancy. Yet we do not understand the neural basis for impaired goal-directed movements in this population. To reach for an object, it is necessary to perceive the state of the arm and the object using multiple sensory modalities (e.g. vision, proprioception), to integrate those sensations into a motor plan, to execute the plan, and to update the plan based on the sensory consequences of action. In this dissertation, I present three studies in which I recorded hand paths of children with ASD and typically developing (TD) …
Identification And Retraining Of Sensorimotor Deficits To Reduce Intention Tremor In Multiple Sclerosis, Megan Heenan
Identification And Retraining Of Sensorimotor Deficits To Reduce Intention Tremor In Multiple Sclerosis, Megan Heenan
Dissertations (1934 -)
Multiple sclerosis (MS) affects approximately 1 in 1000 Americans and is a significant cause of disability in the United States. One significant contributor to disability in MS is intention tremor, which manifests as an oscillation about the endpoint of a goal-directed movement. A major challenge of treating intention tremor is that the underlying causes of tremor in MS are unknown. In this study, we describe a systems-level computational model and an experimental technique that parameterizes subject-specific deficits in sensory feedback control during goal-directed movements. We used this approach to characterize sensorimotor control and examine how sensory and motor processes are …