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Full-Text Articles in Biomedical Engineering and Bioengineering
Protection Against Cardiac Injury By Small Ca2 +-Sensitive K+ Channels Identified In Guinea Pig Cardiac Inner Mitochondrial Membrane, David F. Stowe, Ashish K. Gadicherla, Yifan Zhou, Mohammed Aldakkak, Qunli Cheng, Wai-Meng Kwok, Ming Tao Jiang, James S. Heisner, Meiying Yang, Amadou K.S. Camara
Protection Against Cardiac Injury By Small Ca2 +-Sensitive K+ Channels Identified In Guinea Pig Cardiac Inner Mitochondrial Membrane, David F. Stowe, Ashish K. Gadicherla, Yifan Zhou, Mohammed Aldakkak, Qunli Cheng, Wai-Meng Kwok, Ming Tao Jiang, James S. Heisner, Meiying Yang, Amadou K.S. Camara
Biomedical Engineering Faculty Research and Publications
We tested if small conductance, Ca2 +‐sensitive K+ channels (SKCa) precondition hearts against ischemia reperfusion (IR) injury by improving mitochondrial (m) bioenergetics, if O2‐derived free radicals are required to initiate protection via SKCa channels, and, importantly, if SKCa channels are present in cardiac cell inner mitochondrial membrane (IMM). NADH and FAD, superoxide (O2−), and m[Ca2 +] were measured in guinea pig isolated hearts by fluorescence spectrophotometry. SKCa and IKCa channel opener DCEBIO (DCEB) was given for 10 min and ended 20 min before IR. …