Open Access. Powered by Scholars. Published by Universities.®
Biomedical Engineering and Bioengineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
-
- Abdominal aortic aneurysm (1)
- Adrenal cancer (1)
- Axonal regeneration (1)
- Bacteria Images (1)
- Bacteria Quantification and Detection (1)
-
- COX-2 inhibition (1)
- Cell culture (1)
- Characterization (1)
- Computational model (1)
- Cytometry (1)
- Droplet Classification (1)
- Droplet Microfluidics (1)
- Drug delivery (1)
- E. Coli (1)
- F-actin (1)
- Flow (1)
- Flow cytometry (1)
- GAP-43 (1)
- Growth cones (1)
- Hypoxia (1)
- Inflammation (1)
- Intensity Based Algorithm (1)
- Intra luminal thrombus (1)
- Machine Learning (1)
- Macrophages (1)
- Nanomedicine (1)
- Oxygen transport (1)
- Peripheral neuropathy (1)
- Photoacoustic (1)
- Photoacoustics (1)
Articles 1 - 5 of 5
Full-Text Articles in Biomedical Engineering and Bioengineering
Multiphysics Computational Model Of Fluid Flow And Mass Transport In Aneurysm, Tanja Cupac
Multiphysics Computational Model Of Fluid Flow And Mass Transport In Aneurysm, Tanja Cupac
Electronic Theses and Dissertations
The abdominal aortic aneurysm is progressive, asymptomatic, and can eventually lead to rupture which is a catastrophic event leading to massive internal bleeding and possibly death. AAA cases have been characterized by the development of an intraluminal thrombus (ILT). The ILT correlates with the progression of hypoxia in the arterial wall. The extent that ILT presence reduces oxygen flux to the wall has not been quantified and there is rather a poor understanding of key parameters that can affect thrombus-mediated oxygen transport in AAA. The purpose of this study is to address this gap and to assess the effects of …
Bacteria Analysis By Using A Supervised Machine Learning Algorithm Based On Droplet Microfluidics, Yulder Daniel Angarita
Bacteria Analysis By Using A Supervised Machine Learning Algorithm Based On Droplet Microfluidics, Yulder Daniel Angarita
Electronic Theses and Dissertations
Sepsis is a major medical problem and massive resources have been invested in developing and evaluating alternative treatments. Statistics indicate that sepsis causes between one third and one half of all hospital deaths in the United States. Sepsis has a high impact on health care in the US, with direct sepsis costs in 2009 exceeding $15.4 billion. A research study found that a 1-hour delay in appropriate antimicrobial care resulted in a 7% - 10% rise in mortality. Several professional societies seek to reduce sepsis mortality by targeting the timely use of diagnostic tests and antimicrobial therapy. The diagnostic instruments …
Pilot Study Exploring The Effect Of Targeted Cox-2 Inhibition In Macrophages Responding To Neuronal Injury; Promoting Enhanced Axonal Regeneration, Alyssa Brauckmann
Pilot Study Exploring The Effect Of Targeted Cox-2 Inhibition In Macrophages Responding To Neuronal Injury; Promoting Enhanced Axonal Regeneration, Alyssa Brauckmann
Electronic Theses and Dissertations
Celecoxib nanoemulsion (CXB-NE) has been developed as a macrophage targeted analgesics by Dr. Janjic and her team at Duquesne University, (Janjic et al, 2018; Liu et al, 2020; Saleem et al, 2019b; Vasudeva et al, 2014). The CXB-NE nanoemulsion carrying a Nonsteroidal Anti-inflammatory (NSAID) inhibitor of COX-2 activity result in a reduction in PGE2 expression in macrophages. Using CXB-NE in rats that have peripheral nerve injury constricting the sciatic nerve relieves hypersensitivity, a pain-like behavior. The treatment also decreases inflammation associated with this chronic constriction injury (Janjic et al, 2018; Saleem et al, 2019b; Stevens et al, 2019). In this …
Identification Of Human Adrenal Carcinoma Cells Using Photoacoustic Flow Cytometry, Alexis Stahl
Identification Of Human Adrenal Carcinoma Cells Using Photoacoustic Flow Cytometry, Alexis Stahl
Electronic Theses and Dissertations
With consistently high mortality rates in patients with adrenal cancer, lack of early detection and diagnosis are an ever increasing problem in fighting the deadly disease. Currently, very few patients are diagnosed with adrenal cancer within the early stages due to the absence of symptoms until large tumors are formed, which is in most cases is fatal. Because of this, early detection equipment is crucial to optimizing the survival rate in patients. We studied the absorbance wavelength of human adrenal carcinoma cells, as well as the minimum cell concentration needed in samples using photoacoustic flow cytometry (PAFC). PAFC generates ultrasonic …
Characterization Of Photoacoustic Flow Cytometry Signals, Craig Benzinger
Characterization Of Photoacoustic Flow Cytometry Signals, Craig Benzinger
Electronic Theses and Dissertations
Photoacoustic flow cytometry has been utilized to clinically determine the presence of melanoma circulating tumor cells (CTCs). Further investigation was conducted into the morphology of detection signals and how they could be manipulated to allow for further classification. Novel features were extracted from waveforms that appear to have strong classification ability. Neural networks were also used to determine classification potential and the creation of feature mapping for future unsupervised classification. Detections were expanded from single waves to a time dependent multiwave event. Waveforms were also determined to be of non-parametric distribution, allowing for classification by neural network but not allowing …