Biomedical Engineering and Bioengineering Commons^™

Determining The Transport Enhancement Of Sodium Fluorescein In Mechanically-Loaded Canine Tibia, Andrew Joseph Zak

ETD Archive

Quantitative research concerning the impact of mechanical loading on the transport properties of bone has several critical applications. One such application is the effect of a microgravity environment, where the lack of mechanical forces on bone has been shown to negatively impact both growth and repair. A method has been developed in our lab that can potentially allow for the measurement of the effective permeability of large molecules (i.e., 300-15,000 Da in size) in bone tissue under both unloaded and mechanically loaded conditions. In proof-of-concept experiments, previous students have measured the effective diffusivity of the model solute, sodium fluorescein (376 …