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Full-Text Articles in Biomedical Engineering and Bioengineering
Imaging Of Tyramine-Substituted Hydrogels For Tissue Replacement, Ediuska V. Laurens
Imaging Of Tyramine-Substituted Hydrogels For Tissue Replacement, Ediuska V. Laurens
ETD Archive
Novel tyramine-based hyaluronan (HA) and collagen hydrogels have been developed in which cross-linking is accomplished via peroxidase-mediated dityramine linkages allowing direct cross-linking in vivo. These TB hydrogels possess advantageous physical properties, which include excellent biocompatibility and the ability to mimic the biological, structural and mechanical properties of normal, healthy tissues, including cartilage, and thus provide for synthetic, implantable biomaterials suitable for a wide range of tissue types. The efficacy of these TB-hydrogels has been previously tested in a number of clinically relevant animal models, which have evaluated their applicability for the repair/replacement of various tissues, including cartilage. Nevertheless, there exists …
Cortical Bone Tissue Engineering;Scaffold Design And Cell Selection, Demin Wen
Cortical Bone Tissue Engineering;Scaffold Design And Cell Selection, Demin Wen
ETD Archive
Cortical bone tissue engineering provides a promising approach to generate graft materials needed to treat the large sized bone defects. The underling premise of tissue engineering is to mimic the in vivo microenvironment as best as possible in vitro culture system. To select an appropriate scaffold material used in this model system, mechanical and hydraulic permeability properties of 316L porous stainless steel and polymethylmethacrylate (PMMA) were studied, as well as their biocompatibility in short and long term cell culture. Results showed that scaffolds made of both stainless steel and PMMA: (1) could be manufactured to have similar permeability as that …