Biomedical Engineering and Bioengineering Commons^™

Studying The Interaction Of Antifreeze Proteins (Type I And Type Iii) With The Phospholipid Monolayers At Air/Water Interface, Suresh Essampally

ETD Archive

Heart transplantation is a successful therapeutic procedure for the patients with end stage heart disease. Various preservative techniques have been developed to increase the shelf life of organs, but still there can be tissue damage during cold storage. One mechanism leading to damage is disruption of cell plasma membranes as they pass through temperature induced phase transitions. The addition of antifreeze protein (AFP) or glycoprotein (AFGP) to storage solutions has been hypothesized to reduce the leakiness of lipid membranes. From studies using liposomes it has been shown that AFPs can prevent leakage through lipid membranes, although the mechanism of interaction …