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Full-Text Articles in Biomedical Engineering and Bioengineering
A Protocol For Coupling Volumetrically Dynamic In Vitro Experiments To Numerical Physiology Simulation For A Hybrid Cardiovascular Model, Abraham Umo, Ethan Kung
A Protocol For Coupling Volumetrically Dynamic In Vitro Experiments To Numerical Physiology Simulation For A Hybrid Cardiovascular Model, Abraham Umo, Ethan Kung
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Objective: The Physiology Simulation Coupled Experiment (PSCOPE) is a hybrid modeling framework that enables a physical fluid experiment to operate in the context of a closed-loop computational simulation of cardiovascular physiology. Previous PSCOPE methods coupled rigid experiments to a lumped parameter network (LPN) of physiology but are incompatible with volumetrically dynamic experiments where fluid volume varies periodically. We address this limitation by introducing a method capable of coupling rigid, multi-branch, and volumetrically dynamic in-vitro experiments to an LPN. Methods: Our proposed method utilizes an iterative weighted-averaging algorithm to identify the unique solution waveforms for a given PSCOPE model. We confirm …
Variations In Surgeon-Applied Loads During Passive Range Of Motion Following Total Knee Replacement With Relevance To Computational Modeling, Cj Bakle Ii
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Total knee replacement (TKR) is generally considered a successful treatment for musculoskeletal disorders of the knee. However, as many as 20% of patients report some dissatisfaction in their physical function after TKR. And approximately 50% of early revisions needed to address conditions related to component alignment and soft tissue tension to stabilize the knee. During TKR, surgeons manually perform passive range of motion (ROM) assessments to gain feedback perceived as tension in ligaments and other soft tissues. Such assessments are highly subjective and rely on the surgeon's perception of soft tissue tension rather than quantitative objective means. The variability in …