Biomedical Engineering and Bioengineering Commons^™

Systematic Review And Regression Modeling Of The Effects Of Age, Body Size, And Exercise On Cardiovascular Parameters In Healthy Adults, Aseem Pradhan, John Scaringi, Patrick Gerard, Ross Arena, Jonathan Myers, Leonard A. Kaminsky, Ethan Kung

Publications

Purpose

Blood pressure, cardiac output, and ventricular volumes correlate to various subject features such as age, body size, and exercise intensity. The purpose of this study is to quantify this correlation through regression modeling.

Methods

We conducted a systematic review to compile reference data of healthy subjects for several cardiovascular parameters and subject features. Regression algorithms used these aggregate data to formulate predictive models for the outputs—systolic and diastolic blood pressure, ventricular volumes, cardiac output, and heart rate—against the features—age, height, weight, and exercise intensity. A simulation-based procedure generated data of virtual subjects to test whether these regression models built …

Plaque Contact Surface Area And Flow Lumen Volume Predict Stroke Risk In Extracranial Carotid Artery Stenosis, Ryan Gendey, Ethan Kung, Veena Mehta, Adam Brown, Matthew Bridges, Ravi Veeraswamy

Publications

The standard indication for intervention in asymptomatic disease is currently percent stenosis in the internal carotid artery as measured by the NASCET method, which remains limited in discriminating power. CT angiography (CTA) is widely used to calculate NASCET stenosis but also offers the opportunity to analyze carotid artery plaques from a morphological perspective that has not been widely utilized. We aim to improve stroke risk stratification of patients with carotid artery stenosis using plaque 3D modeling and image analysis. Patients with CTAs appropriate for 3D reconstruction were identified from an NIH designated stroke center database, and carotid arteries were segmented …

Hemodynamic Response To Device Titration In The Shunted Single Ventricle Circulation - A Patient Cohort Modeling Study, Chet Villa, Farha Zafar, Angela Lorts, Ethan Kung

Publications

Clinical outcomes of ventricular assist device (VAD) support for shunted single ventricle patients trail the larger population due in part to the challenges in optimizing VAD support and balancing systemic and pulmonary circulations. We sought to understand the response to VAD titration in the shunted circulation using a lumped-parameter network modeling six patient-specific clinical cases. Hemodynamic data from six patients (mean body surface area = 0.30 m²) with a systemic-to-pulmonary shunt was used to construct simulated cases of heart failure and hemodynamic response to increasing VAD flow from 5 to 10 L/min/m². With increasing VAD flow, …